CORG stands for COmparative Regulatory Genomics. Non-coding DNA segments that are conserved across multiple homologous
genomic sequences are good indicators of putative regulatory elements. We use a systematic
approach to delineate such conserved non-coding blocks from a collection of vertebrate species.
Upstream regions of homologous gene pairs
from man, rhesus monkey, mouse, rat, dog, cow, chicken, tetraodon, zebrafish and xenopus are considered for this purpose.
Pairwise as well as Multiple alignments based on the pairwise ones are available.
News: CORG update based on ENSEMBL 38 (as of 1th September 06)
References:
Dieterich C, Grossmann S, Tanzer A, Ropcke S, Arndt PF, Stadler PF, Vingron M. Comparative promoter region analysis powered by
CORG.BMC Genomics. 2005 Feb 21;6(1):24
Dieterich C, Wang H, Rateitschak K, Luz H, Vingron M.(2003).
CORG: a database for COmparative Regulatory Genomics.
Nucleic Acids Research, 31(1):55-7.
Christoph Dieterich, Brian Cusack, Haiyan Wang, Katja
Rateitschak, Antje Krause and Martin Vingron(2002).
Annotating regulatory DNA based on man-mouse
genomic comparison.
Bioinformatics, 18 Suppl 2:S84-90.
Server maintenance by Christoph Dieterich -
Webmaster
